Title : Effect of tacrolimus on myocardial infarction is associated with inflammation, ROS, MAP kinase and Akt pathways in mini-pigs.

Pub. Date : 2013

PMID : 22972310






2 Functional Relationships(s)
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1 Effect of tacrolimus on myocardial infarction is associated with inflammation, ROS, MAP kinase and Akt pathways in mini-pigs. Tacrolimus AKT serine/threonine kinase 1 Sus scrofa
2 AIM: This study tested the hypothesis that tacrolimus therapy limited left ventricular (LV) infarct and remodeling by suppressing the inflammatory response, oxidative stress and regulating the mitogen-activated protein kinase (MAPK) and Akt signaling pathways in an acute myocardial infarction (AMI) mini-pig model by ligating the left anterior descending coronary artery (LAD). Tacrolimus AKT serine/threonine kinase 1 Sus scrofa