Title : Novel and reversible mechanisms of smoking-induced insulin resistance in humans.

Pub. Date : 2012 Dec

PMID : 22966072






4 Functional Relationships(s)
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1 In muscle cell culture, nicotine exposure significantly increased IRS-1(ser636) phosphorylation and decreased insulin sensitivity, recapitulating the phenotype of smoking-induced insulin resistance in humans. Nicotine insulin Homo sapiens
2 In muscle cell culture, nicotine exposure significantly increased IRS-1(ser636) phosphorylation and decreased insulin sensitivity, recapitulating the phenotype of smoking-induced insulin resistance in humans. Nicotine insulin Homo sapiens
3 Inhibition of mTOR, but not p44/42 MAPK, during nicotine exposure prevented IRS-1(ser636) phosphorylation and normalized insulin sensitivity. Nicotine insulin Homo sapiens
4 These data indicate nicotine induces insulin resistance in skeletal muscle by activating mTOR. Nicotine insulin Homo sapiens