Pub. Date : 2012 Dec
PMID : 22966072
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In muscle cell culture, nicotine exposure significantly increased IRS-1(ser636) phosphorylation and decreased insulin sensitivity, recapitulating the phenotype of smoking-induced insulin resistance in humans. | Nicotine | insulin | Homo sapiens |
| 2 | In muscle cell culture, nicotine exposure significantly increased IRS-1(ser636) phosphorylation and decreased insulin sensitivity, recapitulating the phenotype of smoking-induced insulin resistance in humans. | Nicotine | insulin | Homo sapiens |
| 3 | Inhibition of mTOR, but not p44/42 MAPK, during nicotine exposure prevented IRS-1(ser636) phosphorylation and normalized insulin sensitivity. | Nicotine | insulin | Homo sapiens |
| 4 | These data indicate nicotine induces insulin resistance in skeletal muscle by activating mTOR. | Nicotine | insulin | Homo sapiens |