Title : Excision of 5-hydroxymethyluracil and 5-carboxylcytosine by the thymine DNA glycosylase domain: its structural basis and implications for active DNA demethylation.

Pub. Date : 2012 Nov 1

PMID : 22962365






1 Functional Relationships(s)
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1 We discuss several possible mechanisms, including the amino-imino tautomerization of the substrate base that may explain how TDG discriminates against 5hmC and 5mC. 5-Methylcytosine thymine DNA glycosylase Homo sapiens