Title : Reversion of P-glycoprotein-mediated multidrug resistance by guggulsterone in multidrug-resistant human cancer cell lines.

Pub. Date : 2012 Nov 5

PMID : 22960326






3 Functional Relationships(s)
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1 The results showed that guggulsterone ranging from 2.5 to 80 muM significantly promoted the activity of P-gp ATPase in a dose-dependent manner. pregna-4,17-diene-3,16-dione latexin Homo sapiens
2 After treatment with guggulsterone (1, 3, 10, 30, 100 muM), intracellular pH of K562/DOX cells decreased in a dose- and time-dependent manner. pregna-4,17-diene-3,16-dione latexin Homo sapiens
3 After treatment with guggulsterone (0.1, 1, 10 muM) for 48 h, MCF-7/DOX cells were found to have no change of GCS protein expression amount. pregna-4,17-diene-3,16-dione latexin Homo sapiens