Title : Peroxiredoxin II is essential for preventing hemolytic anemia from oxidative stress through maintaining hemoglobin stability.

Pub. Date : 2012 Sep 28

PMID : 22960070






2 Functional Relationships(s)
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1 Upon oxidative stress, ROS and Heinz body formation were significantly increased in Prx II knockout RBCs compared to wild-type (WT), which ultimately accelerated the accumulation of hemosiderin and heme-oxygenase 1 in the Prx II knock-out livers. Reactive Oxygen Species periaxin Homo sapiens
2 In addition, ROS-dependent Hb aggregation was significantly increased in Prx II knockout RBCs. Reactive Oxygen Species periaxin Homo sapiens