Title : Modulation in selectivity and allosteric properties of small-molecule ligands for CC-chemokine receptors.

Pub. Date : 2012 Sep 27

PMID : 22957890






1 Functional Relationships(s)
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1 Among 18 human chemokine receptors, CCR1, CCR4, CCR5, and CCR8 were activated by metal ion Zn(II) or Cu(II) in complex with 2,2"-bipyridine or 1,10-phenanthroline with similar potencies (EC(50) from 3.9 to 172 muM). 1,10-phenanthroline latexin Homo sapiens