Title : Integration of β-catenin, sirtuin, and FOXO signaling protects from mutant huntingtin toxicity.

Pub. Date : 2012 Sep 5

PMID : 22956852






2 Functional Relationships(s)
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1 In Caenorhabditis elegans, sir-2.1/SIRT1 overexpression protects neurons from the early phases of expanded polyglutamine (polyQ) toxicity, and this protection requires the longevity-promoting factor daf-16/FOXO. polyglutamine Fork-head domain-containing protein;Forkhead box protein O Caenorhabditis elegans
2 In Caenorhabditis elegans, sir-2.1/SIRT1 overexpression protects neurons from the early phases of expanded polyglutamine (polyQ) toxicity, and this protection requires the longevity-promoting factor daf-16/FOXO. polyglutamine Fork-head domain-containing protein;Forkhead box protein O Caenorhabditis elegans