Title : Cytokine and chemokine secretion induced by poly(I:C) through NF-κB and phosphoinositide 3-kinase signaling pathways in human corneal fibroblasts.

Pub. Date : 2013 Jan

PMID : 22954322






2 Functional Relationships(s)
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1 Whereas the poly(I:C)-induced secretion of IL-6, IP-10, and RANTES was inhibited by both IKK-2 inhibitor and LY294002, that of IL-8 was blocked only by IKK-2 inhibitor. Poly I-C interleukin 6 Homo sapiens
2 CONCLUSIONS: The poly(I:C)-induced secretion of IL-6, IP-10, and RANTES from human corneal fibroblasts is mediated by both NF-kappaB and PI3K signaling pathways, whereas that of IL-8 is mediated by the NF-kappaB pathway. Poly I-C interleukin 6 Homo sapiens