Title : Ligand migration in the gaseous insulin-CB7 complex--a cautionary tale about the use of ECD-MS for ligand binding site determination.

Pub. Date : 2012 Nov

PMID : 22948902






2 Functional Relationships(s)
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Protein Name
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1 133:8810-8813, 2011) indicate that CB7 binds selectively to the N-terminal phenylalanine of the insulin B-chain. Phenylalanine insulin Bos taurus
2 Competition experiments employing ESI mass spectrometry to assess complex formation between CB7 and wild type insulin B-chain vs. a mutant B-chain, confirm that the N-terminal phenylalanine plays in important role in solution-phase binding. Phenylalanine insulin Bos taurus