Pub. Date : 2012
PMID : 22938493
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In this study, we aimed to evaluate any positive correlation between COX-2 and ABCG2 gene expression using the COX-2 inducer 12-O-tetradecanoylphorbol-13-acetate (TPA) in human breast cancer cell lines. | Tetradecanoylphorbol Acetate | prostaglandin-endoperoxide synthase 2 | Homo sapiens |
| 2 | In this study, we aimed to evaluate any positive correlation between COX-2 and ABCG2 gene expression using the COX-2 inducer 12-O-tetradecanoylphorbol-13-acetate (TPA) in human breast cancer cell lines. | Tetradecanoylphorbol Acetate | prostaglandin-endoperoxide synthase 2 | Homo sapiens |
| 3 | In this study, we aimed to evaluate any positive correlation between COX-2 and ABCG2 gene expression using the COX-2 inducer 12-O-tetradecanoylphorbol-13-acetate (TPA) in human breast cancer cell lines. | Tetradecanoylphorbol Acetate | prostaglandin-endoperoxide synthase 2 | Homo sapiens |
| 4 | In this study, we aimed to evaluate any positive correlation between COX-2 and ABCG2 gene expression using the COX-2 inducer 12-O-tetradecanoylphorbol-13-acetate (TPA) in human breast cancer cell lines. | Tetradecanoylphorbol Acetate | prostaglandin-endoperoxide synthase 2 | Homo sapiens |
| 5 | A significant increase of COX-2 mRNA expression (up to 11-fold by 4 h) was induced by TPA in MDA-MB-231 cells, this induction effect being lower in MCF-7 cells. | Tetradecanoylphorbol Acetate | prostaglandin-endoperoxide synthase 2 | Homo sapiens |
| 6 | In conclusion, based on the observed effects of TPA in MDA-Mb-231 cells, it is proposed that TPA up-regulates ABCG2 expression in the drug sensitive MCF-7 breast cancer cell line through COX-2 unrelated pathways. | Tetradecanoylphorbol Acetate | prostaglandin-endoperoxide synthase 2 | Homo sapiens |