Pub. Date : 2012 Nov 30
PMID : 22932446
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Kurarinone promotes TRAIL-induced apoptosis by inhibiting NF-kappaB-dependent cFLIP expression in HeLa cells. | kurarinone | TNF superfamily member 10 | Homo sapiens |
| 2 | This study was designed to investigate the effects of the prenylated flavonoid kurarinone on TNF-related apoptosis inducing ligand (TRAIL)-induced apoptosis and its underlying mechanism. | kurarinone | TNF superfamily member 10 | Homo sapiens |
| 3 | This study was designed to investigate the effects of the prenylated flavonoid kurarinone on TNF-related apoptosis inducing ligand (TRAIL)-induced apoptosis and its underlying mechanism. | kurarinone | TNF superfamily member 10 | Homo sapiens |
| 4 | A low dose of kurarinone had no significant effect on apoptosis, but this compound markedly promoted tumor cell death through elevation of Bid cleavage, cytochrome c release release and caspase activation in HeLa cells treated with TRAIL. | kurarinone | TNF superfamily member 10 | Homo sapiens |
| 5 | On the other hand, kurarinone significantly inhibited TRAIL-induced IKK activation, IkappaB degradation and nuclear translocation of NF-kappaB, as well as effectively suppressed cellular FLICE-inhibitory protein long form (cFLIPL) expression. | kurarinone | TNF superfamily member 10 | Homo sapiens |
| 6 | The synergistic effects of kurarinone on TRAIL-induced apoptosis were mimicked when kurarinone was replaced by the NF-kappaB inhibitor withaferin A or following siRNA-mediated knockdown of cFLIPL. | kurarinone | TNF superfamily member 10 | Homo sapiens |
| 7 | The synergistic effects of kurarinone on TRAIL-induced apoptosis were mimicked when kurarinone was replaced by the NF-kappaB inhibitor withaferin A or following siRNA-mediated knockdown of cFLIPL. | kurarinone | TNF superfamily member 10 | Homo sapiens |
| 8 | Moreover, cFLIP overexpression effectively antagonized kurarinone-mediated TRAIL sensitization. | kurarinone | TNF superfamily member 10 | Homo sapiens |
| 9 | These data suggest that kurarinone sensitizes TRAIL-induced tumor cell apoptosis via suppression of NF-kappaB-dependent cFLIP expression, indicating that this compound can be used as an anti-tumor agent in combination with TRAIL. | kurarinone | TNF superfamily member 10 | Homo sapiens |
| 10 | These data suggest that kurarinone sensitizes TRAIL-induced tumor cell apoptosis via suppression of NF-kappaB-dependent cFLIP expression, indicating that this compound can be used as an anti-tumor agent in combination with TRAIL. | kurarinone | TNF superfamily member 10 | Homo sapiens |