Title : Cholinergic modulation by opioid receptor ligands: potential application to Alzheimer's disease.

Pub. Date : 2013 Mar

PMID : 22931533






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Galantamine is a reversible, competitive acetylcholinesterase (AChE) inhibitor and allosteric potentiating ligand of nicotinic acetylcholine receptors (nAChR-APL) that shares many common structural elements with morphinan-based opioids. Galantamine acetylcholinesterase (Cartwright blood group) Homo sapiens
2 Galantamine is a reversible, competitive acetylcholinesterase (AChE) inhibitor and allosteric potentiating ligand of nicotinic acetylcholine receptors (nAChR-APL) that shares many common structural elements with morphinan-based opioids. Galantamine acetylcholinesterase (Cartwright blood group) Homo sapiens
3 The structurally diverse opioids codeine and eseroline, like galantamine, are also nAChR-APL that have greatly diminished affinity for AChE, representing potential lead compounds for selective nAChR-APL development. Galantamine acetylcholinesterase (Cartwright blood group) Homo sapiens