Title : Cancer-associated variants and a common polymorphism of MUTYH exhibit reduced repair of oxidative DNA damage using a GFP-based assay in mammalian cells.

Pub. Date : 2012 Nov

PMID : 22926731






2 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 MUTYH removes adenine misincorporated opposite the DNA oxidation product, 8-oxoguanine (OG), thereby preventing accumulation of G:C to T:A transversion mutations. Adenine mutY DNA glycosylase Homo sapiens
2 The most common cancer-associated MUTYH variant proteins when expressed in bacteria exhibit reduced OG:A mismatch affinity and adenine removal activity. Adenine mutY DNA glycosylase Homo sapiens