Title : Lactic acid is elevated in idiopathic pulmonary fibrosis and induces myofibroblast differentiation via pH-dependent activation of transforming growth factor-β.

Pub. Date : 2012 Oct 15

PMID : 22923663






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Physiologic concentrations of lactic acid induced myofibroblast differentiation via activation of TGF-beta. Lactic Acid transforming growth factor beta 1 Homo sapiens
2 CONCLUSIONS: We have identified the metabolite lactic acid as an important mediator of myofibroblast differentiation via a pH-dependent activation of TGF-beta. Lactic Acid transforming growth factor beta 1 Homo sapiens