Pub. Date : 2012 Nov
PMID : 22922731
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Curcumin inhibits HCV replication by induction of heme oxygenase-1 and suppression of AKT. | Curcumin | heme oxygenase 1 | Homo sapiens |
| 2 | Under the same conditions, curcumin also dose-dependently induced heme oxygenase-1 with the highest induction at 24 h. Hemin, a heme oxygenase-1 inducer, also inhibited HCV protein expression in a dose-dependent manner. | Curcumin | heme oxygenase 1 | Homo sapiens |
| 3 | Under the same conditions, curcumin also dose-dependently induced heme oxygenase-1 with the highest induction at 24 h. Hemin, a heme oxygenase-1 inducer, also inhibited HCV protein expression in a dose-dependent manner. | Curcumin | heme oxygenase 1 | Homo sapiens |
| 4 | The knockdown of heme oxygenase-1 partially reversed the curcumin-inhibited HCV protein expression. | Curcumin | heme oxygenase 1 | Homo sapiens |
| 5 | In addition to the heme oxygenase-1 induction, signaling molecule activities of AKT, extracellular signal-regulated kinases (ERK) and nuclear factor-kappaB (NF-kappaB) were inhibited by curcumin. | Curcumin | heme oxygenase 1 | Homo sapiens |
| 6 | In summary, curcumin inhibited HCV replication by heme oxygenase-1 induction and AKT pathway inhibition. | Curcumin | heme oxygenase 1 | Homo sapiens |