Title : Insulin reduces excitation in gastric-related neurons of the dorsal motor nucleus of the vagus.

Pub. Date : 2012 Oct 15

PMID : 22914748






1 Functional Relationships(s)
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1 Insulin effects were eliminated in the presence of a ATP-dependent K+ (K(ATP)) channel antagonist tolbutamide (200 muM), or the phosphatidylinositol 3-kinase (PI3K) inhibitor wortmannin (100 nM), suggesting that insulin inhibition of excitatory input to gastric-related DMV neurons was mediated by K(ATP) channels and depended on PI3K activity. Adenosine Triphosphate insulin Homo sapiens