Title : The influence of cholinergic agents on histamine release from HMC-1 human mast cell line stimulated with IgG, C-reactive protein and compound 48/80.

Pub. Date : 2012 Nov 27

PMID : 22902499






1 Functional Relationships(s)
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1 KEY FINDINGS: Both nAChR and mAChR antagonists (hexamethonium and methacine, respectively), per se, elevated histamine-releasing activity of the HMC-1 and suppressed the MC responses to most of investigated activators (carbachol, compound 48/80, and to a lesser extent aIgG). Carbachol cholinergic receptor nicotinic alpha 4 subunit Homo sapiens