Title : syn-β-Hydroxyallylic silanes from terminal epoxide α-lithiation-silylation and alkenylation: application to the tetrahydrofuran portion of the lytophilippines.

Pub. Date : 2012 Sep 7

PMID : 22897831






2 Functional Relationships(s)
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1 syn-beta-Hydroxyallylic silanes from terminal epoxide alpha-lithiation-silylation and alkenylation: application to the tetrahydrofuran portion of the lytophilippines. Epoxy Compounds synemin Homo sapiens
2 Lithiation-in situ silylation of terminal epoxides using lithium 2,2,6,6-tetramethylpiperidide in combination with phenyldimethyl(or diethyl)silyl chloride provides a direct process for the synthesis of trans-alpha,beta-epoxysilanes, which undergo alpha-ring opening with alkenylcoppers to give syn-beta-hydroxyallylic silanes. Epoxy Compounds synemin Homo sapiens