Pub. Date : 2012 Oct
PMID : 22892191
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Protective effect of klotho protein against cisplatin ototoxicity in an auditory cell line. | Cisplatin | klotho | Homo sapiens |
| 2 | This study aimed to clarify the effect of klotho expression on cisplatin ototoxicity, using an auditory cell line. | Cisplatin | klotho | Homo sapiens |
| 3 | RESULTS: Klotho protein expression increased in cisplatin-treated auditory cells. | Cisplatin | klotho | Homo sapiens |
| 4 | Cells treated with both klotho protein and cisplatin showed a viability of 67.7 per cent, versus 59.4 per cent in cisplatin-treated cells. | Cisplatin | klotho | Homo sapiens |
| 5 | Klotho significantly attenuated the cisplatin-induced increase in reactive oxygen species, and increased the viability of cells with cisplatin-induced cytotoxicity. | Cisplatin | klotho | Homo sapiens |
| 6 | Klotho significantly attenuated the cisplatin-induced increase in reactive oxygen species, and increased the viability of cells with cisplatin-induced cytotoxicity. | Cisplatin | klotho | Homo sapiens |
| 7 | CONCLUSION: Klotho protein is protective against cisplatin-induced auditory cell cytotoxicity; inhibition of reactive oxygen species may be the main mechanism. | Cisplatin | klotho | Homo sapiens |