Pub. Date : 2012 Oct 1
PMID : 22875784
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In vitro studies using submandibular gland (SMG) cell aggregates isolated from wild-type C57BL/6 mice indicate that treatment with ATP or the high affinity P2X7R agonist 3"-O-(4-benzoyl)benzoyl-ATP (BzATP) induces membrane blebbing and enhances caspase activity, responses that were absent in SMG cell aggregates isolated from mice lacking the P2X7R (P2X7R(-/-)). | 3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate | purinergic receptor P2X, ligand-gated ion channel, 7 | Mus musculus |
| 2 | In vitro studies using submandibular gland (SMG) cell aggregates isolated from wild-type C57BL/6 mice indicate that treatment with ATP or the high affinity P2X7R agonist 3"-O-(4-benzoyl)benzoyl-ATP (BzATP) induces membrane blebbing and enhances caspase activity, responses that were absent in SMG cell aggregates isolated from mice lacking the P2X7R (P2X7R(-/-)). | 3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate | purinergic receptor P2X, ligand-gated ion channel, 7 | Mus musculus |
| 3 | In vitro studies using submandibular gland (SMG) cell aggregates isolated from wild-type C57BL/6 mice indicate that treatment with ATP or the high affinity P2X7R agonist 3"-O-(4-benzoyl)benzoyl-ATP (BzATP) induces membrane blebbing and enhances caspase activity, responses that were absent in SMG cell aggregates isolated from mice lacking the P2X7R (P2X7R(-/-)). | 3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate | purinergic receptor P2X, ligand-gated ion channel, 7 | Mus musculus |
| 4 | Additional studies with SMG cell aggregates indicate that activation of the P2X7R with ATP or BzATP stimulates the cleavage and release of alpha-fodrin, a cytoskeletal protein thought to act as an autoantigen in the development of SS. | 3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate | purinergic receptor P2X, ligand-gated ion channel, 7 | Mus musculus |