Title : Proinflammatory cytokine regulation of cyclic AMP-phosphodiesterase 4 signaling in microglia in vitro and following CNS injury.

Pub. Date : 2012 Dec

PMID : 22865690






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 TNF-alpha or IL-1beta stimulation produced a profound reduction (>90%) of cyclic AMP within EOC2 microglia from 30 min that then recovered after IL-1beta but remained suppressed with TNF-alpha through 24 h. Cyclic AMP was also reduced in TNF-alpha-stimulated primary microglia, albeit to a lesser extent. Cyclic AMP interleukin 1 beta Mus musculus
2 TNF-alpha or IL-1beta stimulation produced a profound reduction (>90%) of cyclic AMP within EOC2 microglia from 30 min that then recovered after IL-1beta but remained suppressed with TNF-alpha through 24 h. Cyclic AMP was also reduced in TNF-alpha-stimulated primary microglia, albeit to a lesser extent. Cyclic AMP interleukin 1 beta Mus musculus
3 These studies show that TNF-alpha and IL-1beta differentially affect cyclic AMP-PDE signaling in microglia. Cyclic AMP interleukin 1 beta Mus musculus