Title : EGFR and PKC are involved in the activation of ERK1/2 and p90 RSK and the subsequent proliferation of SNU-407 colon cancer cells by muscarinic acetylcholine receptors.

Pub. Date : 2012 Nov

PMID : 22865467






4 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 The inhibition of the epidermal growth factor receptor (EGFR) by AG1478 or protein kinase C (PKC) by GF109203X significantly reduced carbachol-stimulated ERK1/2 activation and cell proliferation. Carbachol epidermal growth factor receptor Homo sapiens
2 The inhibition of the epidermal growth factor receptor (EGFR) by AG1478 or protein kinase C (PKC) by GF109203X significantly reduced carbachol-stimulated ERK1/2 activation and cell proliferation. Carbachol epidermal growth factor receptor Homo sapiens
3 Cotreatment of the cells with AG1478 and GF109203X produced an additive effect on carbachol-stimulated ERK1/2 activation, suggesting that the EGFR and PKC pathways act in parallel. Carbachol epidermal growth factor receptor Homo sapiens
4 In SNU-407 cells, carbachol treatment induced RSK activation in an atropine-sensitive manner, and this RSK activation was decreased by the inhibition of either EGFR or PKC. Carbachol epidermal growth factor receptor Homo sapiens