Pub. Date : 2012 Sep
PMID : 22864769
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | TOP2A amplification in breast cancer is a predictive marker of anthracycline-based neoadjuvant chemotherapy efficacy. | Anthracyclines | DNA topoisomerase II alpha | Homo sapiens |
| 2 | Anthracycline is a DNA topoisomerase 2-alpha (TOP2A) inhibitor and its concomitant over expression with Human Epidermal Growth Factor Receptor 2 (HER2) was investigated of being predictive for the response to anthracycline-based chemotherapies in breast cancer. | Anthracyclines | DNA topoisomerase II alpha | Homo sapiens |
| 3 | Anthracycline is a DNA topoisomerase 2-alpha (TOP2A) inhibitor and its concomitant over expression with Human Epidermal Growth Factor Receptor 2 (HER2) was investigated of being predictive for the response to anthracycline-based chemotherapies in breast cancer. | Anthracyclines | DNA topoisomerase II alpha | Homo sapiens |
| 4 | The interaction between HER2 or TOP2A and anthracycline-based regimen was observed in IDD and conventional neoadjuvant chemotherapies. | Anthracyclines | DNA topoisomerase II alpha | Homo sapiens |
| 5 | The TOP2A amplification is related to anthracycline-based neoadjuvant chemotherapy sensitivity, and TOP2A should be included in future studies in breast cancer as a predictive marker. | Anthracyclines | DNA topoisomerase II alpha | Homo sapiens |