Title : Characterization of non-nitrocatechol pan and isoform specific catechol-O-methyltransferase inhibitors and substrates.

Pub. Date : 2012 Feb 15

PMID : 22860182






1 Functional Relationships(s)
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1 Finally, novel non-nitrocatechol COMT inhibitors displayed less potent uncoupling of the mitochondrial membrane potential (MMP) compared to tolcapone as well as nonhepatotoxic entacapone, thus mitigating the risk of hepatotoxicity. entacapone catechol-O-methyltransferase Homo sapiens