Pub. Date : 2012 Feb 15
PMID : 22860182
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Characterization of non-nitrocatechol pan and isoform specific catechol-O-methyltransferase inhibitors and substrates. | nitrocatechol | catechol-O-methyltransferase | Homo sapiens |
| 2 | Subsequent optimization led to the identification of novel, non-nitrocatechol COMT inhibitors, some of which interact specifically with MB-COMT. | nitrocatechol | catechol-O-methyltransferase | Homo sapiens |
| 3 | Finally, novel non-nitrocatechol COMT inhibitors displayed less potent uncoupling of the mitochondrial membrane potential (MMP) compared to tolcapone as well as nonhepatotoxic entacapone, thus mitigating the risk of hepatotoxicity. | nitrocatechol | catechol-O-methyltransferase | Homo sapiens |