Pub. Date : 2012
PMID : 22860104
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Effects of niacin restriction on sirtuin and PARP responses to photodamage in human skin. | Niacin | poly(ADP-ribose) polymerase 1 | Homo sapiens |
| 2 | Niacin restriction, which decreases NAD(+), the sirtuin substrate, results in an increase in acetylated proteins, upregulation of SIRTs 2 and 4, increased inherent DNA damage, alterations in SIRT responses to photodamage, abrogation of PARP activation following photodamage, and increased sensitivity to photodamage that is completely reversed by repleting niacin. | Niacin | poly(ADP-ribose) polymerase 1 | Homo sapiens |