Title : p14ARF post-transcriptional regulation of nuclear cyclin D1 in MCF-7 breast cancer cells: discrimination between a good and bad prognosis?

Pub. Date : 2012

PMID : 22860097






1 Functional Relationships(s)
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1 Our results show that activation of the p14ARF-p53-p21-Rb pathway in the estrogen sensitive MCF-7 breast cancer cells induces many hallmarks of senescence including a large flat cell morphology, multinucleation, senescence-associated-beta-gal staining, and rapid G1 and G2/M phase cell cycle arrest. beta-D-galactose cyclin dependent kinase inhibitor 2A Homo sapiens