Title : Warburg effect's manifestation in aggressive pheochromocytomas and paragangliomas: insights from a mouse cell model applied to human tumor tissue.

Pub. Date : 2012

PMID : 22859959






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 To date, the molecular mechanisms causing the more aggressive phenotype in SDHB-PHEOs/PGLs remain largely unknown. pheos succinate dehydrogenase complex iron sulfur subunit B Homo sapiens
2 Although there was no direct evidence for increased reactive oxygen species production, elevated superoxide dismutase 2 expression may reflect elevated oxidative stress in SDHB-derived PHEOs/PGLs. pheos succinate dehydrogenase complex iron sulfur subunit B Homo sapiens
3 In addition, we present evidence for increased LDHA and SOD2 expression in SDHB-PHEOs/PGLs, proteins that have been proposed as promising therapeutic targets in other cancers. pheos succinate dehydrogenase complex iron sulfur subunit B Homo sapiens