Pub. Date : 2014 Jun
PMID : 22859221
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Inhibition of PI3K/Akt which negatively regulates GSK3 activity by LY294002 resulted in a decrease in arsenite-mediated beta-catenin nuclear accumulation, and VEGF expression. | arsenite | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | These results suggested that beta-catenin plays a role in arsenite-induced VEGF in SH-SY5Y cells, and the induction of beta-catenin by arsenite is mediated by inhibition of GSK3 without activating its upstream kinase Akt. | arsenite | AKT serine/threonine kinase 1 | Homo sapiens |