Pub. Date : 2012 Sep
PMID : 22846842
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In addition, CsA compromised the UVB-induced checkpoint function by upregulating the molecular chaperone protein cyclophilin A (CypA). | Cyclosporine | peptidylprolyl isomerase A | Homo sapiens |
| 2 | In addition, CsA compromised the UVB-induced checkpoint function by upregulating the molecular chaperone protein cyclophilin A (CypA). | Cyclosporine | peptidylprolyl isomerase A | Homo sapiens |
| 3 | CsA-induced phosphoinositide 3-kinase(PI3K)/AKT activation was required for both XPC suppression and CypA upregulation. | Cyclosporine | peptidylprolyl isomerase A | Homo sapiens |
| 4 | Our findings identified deregulation of XPC and CypA as key targets of CsA, and UVB damage and PI3K/AKT activation as two principal drivers for CsA-sensitized skin tumorigenesis, further supporting an immunosuppression-independent mechanism of CsA action on skin tumorigenesis. | Cyclosporine | peptidylprolyl isomerase A | Homo sapiens |