Title : The preparation of a complex of insulin-phospholipids and their interaction mechanism.

Pub. Date : 2012 Sep

PMID : 22833363






6 Functional Relationships(s)
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1 The preparation of a complex of insulin-phospholipids and their interaction mechanism. Phospholipids insulin Homo sapiens
2 In this paper, we developed a novel technique to fabricate the insulin-phospholipids complex by a solvent evaporation method with the aim of improving the lipophilicity of insulin. Phospholipids insulin Homo sapiens
3 In this paper, we developed a novel technique to fabricate the insulin-phospholipids complex by a solvent evaporation method with the aim of improving the lipophilicity of insulin. Phospholipids insulin Homo sapiens
4 A systematic study on the preparation conditions of the insulin-phospholipids complex is reported in the present work. Phospholipids insulin Homo sapiens
5 The associated efficiency of the phospholipids and insulin can be up to 100% when their mass ratio is 7.5 : 1 or more, and the solubility of the complex is improved more than 40 000 times compared with that of insulin alone in the n-octyl alcohol. Phospholipids insulin Homo sapiens
6 The stability results showed that the complex was stable for 1 year at -20 C. The interaction mechanism of this formation is that the peptide bonds of insulin interact with the water-soluble head of phospholipids, forming a reverse micelle-like structure. Phospholipids insulin Homo sapiens