Title : The Nlrp3 inflammasome promotes age-related thymic demise and immunosenescence.

Pub. Date : 2012 Jan 26

PMID : 22832107






1 Functional Relationships(s)
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1 Here we show that age-related increase in "lipotoxic danger signals" such as free cholesterol (FC) and ceramides, leads to thymic caspase-1 activation via the Nlrp3 inflammasome. Cholesterol NLR family pyrin domain containing 3 Homo sapiens