Title : Luteinizing hormone/human chorionic gonadotropin-mediated activation of mTORC1 signaling is required for androgen synthesis by theca-interstitial cells.

Pub. Date : 2012 Oct

PMID : 22827930






2 Functional Relationships(s)
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1 Furthermore, pharmacological targeting of mTORC1 with rapamycin also blocked LH/hCG- or forskolin-induced expression of cAMP response element-binding protein (CREB) and steroidogenic enzymes (P450 side-chain cleavage enzyme, 3beta-hydroxysteroid dehydrogenase type 1, and 17alpha-hydroxylase/17,20 lyase) but produced no effect on steroidogenic acute regulatory protein levels. Colforsin cAMP responsive element binding protein 1 Homo sapiens
2 Furthermore, pharmacological targeting of mTORC1 with rapamycin also blocked LH/hCG- or forskolin-induced expression of cAMP response element-binding protein (CREB) and steroidogenic enzymes (P450 side-chain cleavage enzyme, 3beta-hydroxysteroid dehydrogenase type 1, and 17alpha-hydroxylase/17,20 lyase) but produced no effect on steroidogenic acute regulatory protein levels. Colforsin cAMP responsive element binding protein 1 Homo sapiens