Pub. Date : 2012 Sep
PMID : 22820913
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Using microspectrofluorimetry (indo-1), we show that capsaicin and 4alpha-phorbol-12,13-didecanoate (4alpha-PDD), selective agonists of TRPV1 and TRPV4, respectively, increased the intracellular calcium concentration of PASMC. | pasmc | transient receptor potential cation channel, subfamily V, member 1 | Rattus norvegicus |
| 2 | Furthermore, stimulation of TRPV1 and TRPV4 induced PASMC migratory responses, as assessed by two different methods (a modified Boyden chamber assay and a wound-healing migration assay). | pasmc | transient receptor potential cation channel, subfamily V, member 1 | Rattus norvegicus |
| 3 | In conclusion, these data point out, for the first time, the implication of TRPV1 and TRPV4 in rat PASMC migration, suggesting the implication of these TRPV channels in the physiopathology of pulmonary hypertension. | pasmc | transient receptor potential cation channel, subfamily V, member 1 | Rattus norvegicus |