Pub. Date : 2012
PMID : 22815988
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The time-course change in the phenobarbital-mediated down-regulation of miR-122 was inversely correlated with AMPK activation. | Phenobarbital | microRNA 122 | Homo sapiens |
| 2 | Phenobarbital decreased primary miR-122 to approximately 25% of the basal level as early as 1 h and suppressed transactivity of mir-122 promoter in HuH-7 cells, suggesting that the down-regulation occurred at the transcriptional level. | Phenobarbital | microRNA 122 | Homo sapiens |
| 3 | Phenobarbital decreased primary miR-122 to approximately 25% of the basal level as early as 1 h and suppressed transactivity of mir-122 promoter in HuH-7 cells, suggesting that the down-regulation occurred at the transcriptional level. | Phenobarbital | microRNA 122 | Homo sapiens |
| 4 | An inhibitory RNA specific for miR-122 increased activated AMPK and CAR-mediated trancactivation of the phenobarbital-responsive enhancer module in HepG2 cells. | Phenobarbital | microRNA 122 | Homo sapiens |
| 5 | Taken together, these results suggest that phenobarbital-mediated down-regulation of miR-122 is an early and important event in the AMPK-dependent CAR activation and transactivation of its target genes. | Phenobarbital | microRNA 122 | Homo sapiens |