Title : A novel anti-DR5 chimeric antibody and epirubicin synergistically suppress tumor growth.

Pub. Date : 2012 Sep

PMID : 22815059






1 Functional Relationships(s)
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1 The anthracycline anticancer drug epirubicin (EPB) synergizes the cytotoxicity of HMCAZ5 in cancer cells by upregulating DR5 expression on the cell surfaces, enhancing p53 expression, Bid cleavage, and JNK phosphorylation and downregulating c-FLIP expression and Akt phosphorylation. Epirubicin mitogen-activated protein kinase 8 Homo sapiens