Title : Early steps of microglial activation are directly affected by neuroprotectant FK506 in both in vitro inflammation and in rat model of stroke.

Pub. Date : 2012 Dec

PMID : 22806180






1 Functional Relationships(s)
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1 While both drugs efficiently reduced the expression of iNOS and the release of nitric oxide, only FK506 strongly inhibited the expression of Cox-2 and secretion of the mature form of IL-1beta. Tacrolimus interleukin 1 beta Rattus norvegicus