Title : Proline dehydrogenase is essential for proline protection against hydrogen peroxide-induced cell death.

Pub. Date : 2012 Sep 1

PMID : 22796327






2 Functional Relationships(s)
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1 A significant increase in Akt activation was observed in proline-treated cells after hydrogen peroxide stress along with a corresponding increase in the phosphorylation of the forkhead transcription factor class O3a (FoxO3a). Proline AKT serine/threonine kinase 1 Homo sapiens
2 The results provide evidence that PRODH is essential in proline protection against hydrogen peroxide-mediated cell death and that proline/PRODH helps activate Akt in cancer cells. Proline AKT serine/threonine kinase 1 Homo sapiens