Pub. Date : 2012 Sep 1
PMID : 22796327
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Proline dehydrogenase is essential for proline protection against hydrogen peroxide-induced cell death. | Proline | proline dehydrogenase 1 | Homo sapiens |
| 2 | Proline is oxidized to glutamate in the mitochondria, with the rate-limiting step catalyzed by proline dehydrogenase (PRODH). | Proline | proline dehydrogenase 1 | Homo sapiens |
| 3 | Proline is oxidized to glutamate in the mitochondria, with the rate-limiting step catalyzed by proline dehydrogenase (PRODH). | Proline | proline dehydrogenase 1 | Homo sapiens |
| 4 | PRODH expression is inducible by p53, leading to increased proline oxidation, reactive oxygen species formation, and induction of apoptosis. | Proline | proline dehydrogenase 1 | Homo sapiens |
| 5 | Inhibition or siRNA-mediated knockdown of PRODH abolished proline protection against oxidative stress, whereas knockdown of Delta(1)-pyrroline-5-carboxylate reductase, a key enzyme in proline biosynthesis, had no impact on proline protection. | Proline | proline dehydrogenase 1 | Homo sapiens |
| 6 | The role of PRODH in proline-mediated protection was validated in the prostate carcinoma cell line PC3. | Proline | proline dehydrogenase 1 | Homo sapiens |
| 7 | The results provide evidence that PRODH is essential in proline protection against hydrogen peroxide-mediated cell death and that proline/PRODH helps activate Akt in cancer cells. | Proline | proline dehydrogenase 1 | Homo sapiens |
| 8 | The results provide evidence that PRODH is essential in proline protection against hydrogen peroxide-mediated cell death and that proline/PRODH helps activate Akt in cancer cells. | Proline | proline dehydrogenase 1 | Homo sapiens |