Title : Oxidized low-density lipoprotein induces secretion of interleukin-1β by macrophages via reactive oxygen species-dependent NLRP3 inflammasome activation.

Pub. Date : 2012 Aug 24

PMID : 22796220






2 Functional Relationships(s)
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1 Oxidized low-density lipoprotein induces secretion of interleukin-1beta by macrophages via reactive oxygen species-dependent NLRP3 inflammasome activation. Reactive Oxygen Species NLR family pyrin domain containing 3 Homo sapiens
2 Here we show that the phagocytosis of ox-LDL can induce human macrophages to secrete IL-1beta by activating the NLRP3 inflammasome, and we further show that the activation of the NLRP3 inflammasome is dependent on the generation of reactive oxygen species and is related to the cathepsin B pathway. Reactive Oxygen Species NLR family pyrin domain containing 3 Homo sapiens