Title : Effects of chronic nicotine on the autocrine regulation of pancreatic cancer cells and pancreatic duct epithelial cells by stimulatory and inhibitory neurotransmitters.

Pub. Date : 2012 Sep

PMID : 22791813






1 Functional Relationships(s)
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1 The resulting increase in catecholamine production was associated with significant inductions in the phosphorylation of signaling proteins ERK, CREB, Src and AKT, upregulated protein expression of nAChR subunits alpha3, alpha4, alpha5 and alpha7 and increased responsiveness to nicotine in 3-(4,5-dimethylthiazole-2-yl)-2,5-diphenyl tetrazolium bromide and cell migration assays. Catecholamines cAMP responsive element binding protein 1 Homo sapiens