Title : Differential inducing effect of benzo[a]pyrene on gene expression and enzyme activity of cytochromes P450 1A1 and 1A2 in Sprague-Dawley and Wistar rats.

Pub. Date : 2012

PMID : 22785257






1 Functional Relationships(s)
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1 Inhibition studies and kinetic analyses confirmed literature data indicating that methoxyresorufin is a specific CYP1A2 substrate in both uninduced and BaP-treated rats, whereas ethoxyresorufin is a specific CYP1A1 substrate only in BaP-treated rats. Benzo(a)pyrene cytochrome P450, family 1, subfamily a, polypeptide 2 Rattus norvegicus