Title : Differential concentration and time dependent effects of progesterone on kinase activity, hyperactivation and acrosome reaction in human spermatozoa.

Pub. Date : 2012 Oct

PMID : 22775762






1 Functional Relationships(s)
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1 These results imply that although the spermatozoa are sensitive to low concentrations of progesterone, they only activate motility and tyrosine kinase activation; higher concentrations are required to induce hyperactivation and acrosome reaction probably by activating multiple kinase pathways including the MAPK and AKT. Progesterone mitogen-activated protein kinase 3 Homo sapiens