Title : Effect of peginterferon alfa-2a (40KD) on cytochrome P450 isoenzyme activity.

Pub. Date : 2013 Feb

PMID : 22765278






1 Functional Relationships(s)
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1 METHODS: Fourteen healthy, male volunteers aged 18 to 45 years were recruited into an open label, two period, single centre study in which CYP enzyme activity was measured by administration of the selectively metabolized probe drugs theophylline (CYP1A2), tolbutamide (CYP2C9), mephenytoin (CYP2C19), debrisoquine (CYP2D6) and dapsone (CYP3A4) on day 1 of the study. Theophylline cytochrome P450 family 4 subfamily F member 3 Homo sapiens