Title : The effect of tyrphostins AG494 and AG1478 on the autocrine growth regulation of A549 and DU145 cells.

Pub. Date : 2012 Jul 5

PMID : 22763976






2 Functional Relationships(s)
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1 Both EGFR"s inhibitors induced apoptosis of the investigated lung and prostate cancer cell lines, but the proapoptotic effect of the investigated tyrphostins was greater in A549 than in DU145 cells. Tyrphostins epidermal growth factor receptor Homo sapiens
2 The tyrphostins arrested cell growth of DU145 and A549 cells in the G1 phase, similarly to other known inhibitors of EGFR. Tyrphostins epidermal growth factor receptor Homo sapiens