Title : Cancer-stimulated mesenchymal stem cells create a carcinoma stem cell niche via prostaglandin E2 signaling.

Pub. Date : 2012 Sep

PMID : 22763855






1 Functional Relationships(s)
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1 Here we show that tumor cells are able to elicit a strong induction of the COX-2/microsomal prostaglandin-E synthase-1 (mPGES-1)/PGE(2) axis in MSCs recruited to the tumor-associated stroma by releasing IL-1, which in turn elicits a mesenchymal/stem cell-like phenotype in the carcinoma cells. Prostaglandins E mitochondrially encoded cytochrome c oxidase II Homo sapiens