Title : Double-stranded RNA induces IL-8 and MCP-1 gene expression via TLR3 in HaCaT-keratinocytes.

Pub. Date : 2012 Oct

PMID : 22762377






2 Functional Relationships(s)
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1 While poly(I:C) induced IL-8 gene expression was solely inhibited by the NF-kappaB inhibitor III, MCP-1 gene induction was also blocked by PKA, p38 MAPK and JAK-STAT inhibitors. Poly I-C C-C motif chemokine ligand 2 Homo sapiens
2 These data are indicative for distinct signalling pathways in the poly(I:C)-induced gene expression of IL-8 and MCP-1 in HaCaT keratinocytes. Poly I-C C-C motif chemokine ligand 2 Homo sapiens