Title : Phosphatidic acid mediates the targeting of tBid to induce lysosomal membrane permeabilization and apoptosis.

Pub. Date : 2012 Oct

PMID : 22761256






2 Functional Relationships(s)
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1 We found that caspase 8-cleaved Bid (tBid) could result in LMP directly. tBID BH3 interacting domain death agonist Homo sapiens
2 We further noted that chymotrypsin-cleaved Bid is more potent than tBid at binding to PA, inserting into the lipid bilayer, and promoting LMP. tBID BH3 interacting domain death agonist Homo sapiens