Pub. Date : 2012 Aug 10
PMID : 22753408
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Dopamine- and cAMP-regulated phosphoprotein of 32-kDa (DARPP-32)-dependent activation of extracellular signal-regulated kinase (ERK) and mammalian target of rapamycin complex 1 (mTORC1) signaling in experimental parkinsonism. | Cyclic AMP | mitogen-activated protein kinase 1 | Homo sapiens |
| 2 | Dopamine- and cAMP-regulated phosphoprotein of 32-kDa (DARPP-32)-dependent activation of extracellular signal-regulated kinase (ERK) and mammalian target of rapamycin complex 1 (mTORC1) signaling in experimental parkinsonism. | Cyclic AMP | mitogen-activated protein kinase 1 | Homo sapiens |
| 3 | We also show that mutation of the phosphorylation site for cAMP-dependent protein kinase on DARPP-32 attenuates l-DOPA-induced dyskinesia and reduces the concomitant activations of ERK and mTORC1 signaling. | Cyclic AMP | mitogen-activated protein kinase 1 | Homo sapiens |
| 4 | These studies demonstrate that, in D1R-expressing MSNs, l-DOPA-induced activation of ERK and mTORC1 requires DARPP-32 and indicates the importance of the cAMP/DARPP-32 signaling cascade in dyskinesia. | Cyclic AMP | mitogen-activated protein kinase 1 | Homo sapiens |